5c–d). CX-5461-mediated S33 phosphorylation of RPA was impartial on the mobile cycle stage and wasn't limited into the nucleoli in HR-deficient cells. Thus, the development of ssDNA constructions in CX-5461 handled cells can result in replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication stress which could underpin https://garrettyrixh.blogdigy.com/the-best-side-of-g150-40952167