Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts through the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have discovered recurrent mutations in genes regulating tumor cell-microenvironment inter... https://juliec086wel2.wikipowell.com/user