You will find there's release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to minimize afferent pain transmission and create analgesia. Consequently, medication like clonidine that target alpha-2 receptors can affect the transmission of ache. One of several theories with regards https://kylergbtla.tinyblogging.com/considerations-to-know-about-onolidine-75820081