Since creating causation by means of experimental trials was impossible resulting from moral restrictions, a lengthy research was executed in order to establish the solid association required to allow for legislative motion towards smoking cigarettes tobacco.[citation needed] In cigarette smoking, long-term exposure to compounds located in the smoke (e.g., https://oraco57912.wikijm.com/1369967/how_much_you_need_to_expect_you_ll_pay_for_a_good_smoking